HISTONE DEACETYLASE INHIBITORS IMPROVE THE REPLICATION OF ONCOLYTIC HERPES SIMPLEX VIRUS IN BREAST CANCER CELLS.

Histone deacetylase inhibitors improve the replication of oncolytic herpes simplex virus in breast cancer cells.

New therapies are needed for metastatic breast cancer patients.Oncolytic herpes simplex virus (oHSV) is an exciting 3 nef runes therapy being developed for use against aggressive tumors and established metastases.Although oHSV have been demonstrated safe in clinical trials, a lack of sufficient potency has slowed the clinical application of this ap

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Exploring Stakeholder Perspectives on the Barriers and Facilitators of Implementing Digital Technologies for Heart Disease Diagnosis: Qualitative Study

BackgroundDigital technologies are increasingly being implemented in health care to improve the quality and efficiency of silbrade care for patients.However, the rapid adoption of health technologies over the last 5 years has failed to adequately consider patient and clinician needs, which results in ineffective implementation.There is also a lack

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The Effect of Attitude and Economic Foundations on Criminal Policy Making in the Field of Intellectual Property

Today, the traces of intellectual property rights can be seen in all fields.On the other hand, the economy has long been necessary for the progress and continuity of a country.Intellectual property rights have a direct and indirect 2007 toyota sienna manual relationship with economic growth and development, with efficient and appropriate laws in th

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A wind-driven snow redistribution module for Alpine3D v3.3.0: adaptations designed for downscaling ice sheet surface mass balance

Ice sheet surface mass balance describes the net snow accumulation at the ice sheet surface.On vush gloss bullet vibrator the Antarctic ice sheet, winds redistribute snow, resulting in a surface mass balance that is variable in both space and time.Representing wind-driven snow redistribution processes in models is critical for local assessments of

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